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Ibotenic Acid Biosynthesis In The Fly Agaric Is Initiated By Glutamate Hydroxylation

Posted on July 7, 2025

As a result, it has strong neuronal excitatory properties and acts as a potent neurotoxin [18]. Ibotenic acid can induce seizures and lesions in specific brain areas, mirroring the lesions observed in Alzheimer’s disease. Remarkably, fliegenpilz kaufen caused by ibotenic acid has facilitated its utilization in animals to develop Alzheimer’s disease models [16,19]. Together with agarin, ibotenic acid is responsible for the hallucinogenic effects of fly agaric. In humans, the dose of ibotenic acid to cause psychedelic effects ranges from 30 to 60 mg/kg [19].

Folklore & Traditional Use Of Fly Agaric Mushrooms

Like all Amanita species, the mushroom starts its growth by “hatching” from an egg-like sac called a universal veil. As the mushroom grows, this veil breaks leaving concentric scaly rings at the bulbous base of the stem—a feature that is often used to tell it apart from similar species. In conclusion, the psychedelic use of Amanita Muscaria mushrooms has been a topic of interest for centuries, with a rich history of shamanic entheogenic use. While the effects of these mushrooms can vary from person to person, there is a growing body of evidence suggesting potential health benefits such as pain relief, improved sleep, and reduced anxiety.

Amanita Muscaria: Identification, Differences

There are many different varieties of amanita muscaria with varying appearances. The fly agaric also has some interesting ties to the Christmas holiday. Siberian shamans have a tradition of dressing in red robes with white spots in honor of the mushrooms they harvest for religious rituals. In some European countries caps of Amanita muscaria are crumbled up and placed in saucers of milk to attract house flies. The specific epithet muscaria comes from the Latin word musca, meaning ‘a fly’. Welcome to the shady forests of Europe, North America, and Asia.

Analyses were carried out on exsiccatae, and losses may have occurred in the drying process. Furthermore, the time between collecting (and drying) of the mushrooms and their chemical analyses was sometimes longer than 6 months. It would therefore be interesting to repeat the study on fresh material, and to include also collections from Germany (Harz, Erzgebirge). To exclude confusion with other Amanita spp, it is recommended to screen all collections for the characteristic trace elements vanadium and selenium.

Amanita chrysoblema, with the common name American fly agaric, yellow/orange variant, is a basidiomycete fungus of the genus Amanita. Although named chrysoblema, it is traditionally thought to be an Amanita muscaria variant, a group of fungi commonly known as fly agarics. The eastern yellow fly agaric can be found growing singly or in small groups of individual mushrooms.

The focus has shifted from mystical experiences to measured, therapeutic uses, reflecting a more mindful approach to this ancient mushroom. Some reports suggest the shamans that used Amanita muscaria would often wear clothes inspired by the mushroom. Living in a very cold region of the world, they would wear thick layers of clothing dyed red and white to match the distinct color scheme of the fly agaric mushroom.

The poisonous varieties of the Amanita family cause painful deaths as they attack the liver. The muscimol and ibotenic acid in Amanita extracts trigger psychoactive effects at different doses. It is important to note that this list is not exhaustive and that there may be other drugs or foods that can interact with Amanita Muscaria.

There is no antidote, but supportive treatment is usually enough to keep a person safe. This is often necessary due to agitation, auditory and visual hallucinations, delirium, and seizures. Amanita chrysoblema (Amanita muscaria var. alba) is entirely white.

In Stockholm, he published a book outlining the 12 years he spent in a Siberian prison. The suggestion is that the Tree of the Knowledge of Good and Evil is shown to produce Amanita muscaria in the fresco. The art was created in the 1200s, and controversial archaeologist John Allegro claims it is further proof that the mushroom was widely known and used many centuries ago. Furthermore, since it is necessary to decarb Amanita muscaria for safety reasons, the shaman would dry the mushrooms and hang them in a sock over a fireplace. Villagers believed that the shaman could fly or else he would distribute the mushrooms with the help of reindeer. The festival took place each year on the Winter Solstice, which is days away from Christmas Day.

Dry in a food dehydrator, or in the warm air above a fire, or in a warm airing cupboard. You can use these to spread the fly agaric spore to another birch, oak or pine. This alters consciousness and can trigger latent mental problems that would not have triggered without taking this hallucinogenic product. However, what is often reported are hilarious hallucinations, involuntary movements, delirium, vomiting & nausea… This hallucinatory phase is very often followed by depressing thoughts and significant fatigue. Fly Agaric stems are 10 to 25cm long and 1.5 to 2cm in diameter; white and ragged with a grooved, hanging white ring. Amanita muscaria is an introduced species in New Zealand, Tasmania and Australia, where there are concerns that the Fly Agaric may be spreading at the expense of native fungal species.

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